Basic Medical BioChemistry

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Contents


SECTION I

Fuel Metabolism

Metabolic Fuels and Dietary Components

The Fed or Absorptive State

Fasting

SECTION II

Chemical and Biologic Foundations of Biochemistry

Water, Acids, Bases, and Buffers

Structures of the Major Compounds of the Body

Amino Acids in Proteins

Structure–Function Relationships in Proteins

Enzymes as Catalysts

Regulation of Enzymes

Cell Structure and Signaling by Chemical Messengers

Structure of the Nucleic Acids

SECTION III

Gene Expression and the Synthesis of Proteins

Synthesis of DNA

Transcription: Synthesis of RNA

Translation: Synthesis of Proteins

Regulation of Gene Expression

Use of Recombinant DNA Techniques in Medicine

The Molecular Biology of Cancer

An Introduction to Human Genetics

SECTION IV

Carbohydrate Metabolism, Fuel Oxidation, and the Generation of Adenosine

Triphosphate

Basic Concepts in the Regulation of Fuel Metabolism by Insulin, Glucagon, and Other

Hormones

Cellular Bioenergetics: Adenosine Triphosphate and O2

Digestion, Absorption, and Transport of Carbohydrates

Generation of Adenosine Triphosphate from Glucose, Fructose, and Galactose:

Glycolysis

Tricarboxylic Acid Cycle

Oxidative Phosphorylation and Mitochondrial Function

Oxygen Toxicity and Free-Radical Injury

Formation and Degradation of Glycogen

Pentose Phosphate Pathway and the Synthesis of Glycosides, Lactose, Glycoproteins,

and Glycolipids

Gluconeogenesis and Maintenance of Blood Glucose Levels

SECTION V

Lipid Metabolism

Digestion and Transport of Dietary Lipids

Oxidation of Fatty Acids and Ketone Bodies

Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane Lipids

Cholesterol Absorption, Synthesis, Metabolism, and Fate

Metabolism of Ethanol

Integration of Carbohydrate and Lipid Metabolism

SECTION VI

Nitrogen Metabolism

Protein Digestion and Amino Acid Absorption

Fate of Amino Acid Nitrogen: Urea Cycle

Synthesis and Degradation of Amino Acids

Tetrahydrofolate, Vitamin B12


, and S-Adenosylmethionine


Purine and Pyrimidine Metabolism

Intertissue Relationships in the Metabolism of Amino Acids

SECTION VII

Tissue Metabolism

Actions of Hormones That Regulate Fuel Metabolism

The Biochemistry of Erythrocytes and Other Blood Cells

Blood Plasma Proteins, Coagulation, and Fibrinolysis

Liver Metabolism

Metabolism of Muscle at Rest and during Exercise



Metabolism of the Nervous System

The Extracellular Matrix and Connective Tissue

Patient Index

Subject Index

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